Syringe device fixable on a flask

ABSTRACT

An assembly comprising a flanged flask and a syringe device fixable thereto is provided. The syringe device includes a guide member for cooperating with the body of the flask. The guide member includes a first end with an internal guide surface at its terminal portion and a fastening mechanism set back from the internal guide surface. The internal guide surface cooperates with the cylindrical body of the flask and the fastening mechanism attached to the flange of the flask. A second end of the guide member provides translational guidance to a syringe.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to a syringe device fixable on a flask, inparticular a flask containing a liquid to be injected or a substancethat has been lyophilized and that is to be mixed with a physiologicalliquid or with medication so that the mixture can be injected.

2. Description of Related Art

There exist known substances, particularly in the medical field, whichneed to be stored separately and which should be mixed only immediatelyprior to being injected into a patient, e.g. subcutaneously,intravenously, or into muscle. This applies in particular to medicalsubstances which are prepared in lyophilized (freeze dried) form, or inpowder form, and which need to be mixed with a solvent, e.g.physiological serum, for administration to a patient. In other cases,the two components that are mixed together may both be liquids, when theliquids cannot be stored for long periods of time when mixed together.

The most commonly used technique is to store the powder in a separatereceptacle which is closed by a membrane or a leakproof plug that can bepunctured by means of a needle. Then, using a syringe of standard type,a certain quantity of solvent is taken from a second receptacle and theappropriate quantity of solvent is injected into the first receptaclethrough the membrane. The content of the first receptacle is then mixedtogether and the same syringe is then used to suck up the mixture. Thesyringe is then ready for injecting the medication.

In other known techniques, the liquid, e.g. physiological serum, isalready contained in the syringe. It then suffices to inject the liquidthrough the puncturable membrane into the receptacle containing thesubstance in powder form, to mix the substances together, and then suckthe mixture back into the syringe.

However, that technique suffers from certain difficulties in use. Inparticular, when the flask containing the powder has a neck of smalldiameter, it is difficult to puncture the puncturable plugappropriately. An essential condition for extracting all of the liquidcontained in the flask after the powder has been mixed with the solventis for the puncturable plug to be punctured in its center and for theneedle to be inserted as small a distance as possible into the flask.That also serves to avoid wetting the needle while mixing is beingperformed, thus leaving the needle in a condition suitable for beingreused to inject the mixture into the patient. Unfortunately, as alreadymentioned, when the neck of the flask is of small diameter, this can bedifficult to do. There also exists a non-negligible risk of the user,e.g. a nurse, pricking a finger while performing the above operation.

An object of the present invention is to provide a syringe device thatis fixable on a flask and which ensures that the puncturable plug ispunctured in its center and which also makes this operation veryreliable and completely repeatable. Another object of the presentinvention is to provide such a device which can be fitted onto a flaskcommonly used for containing medicinal powders for mixing with asolvent, and in particular substances that have been lyophilized.

SUMMARY OF THE INVENTION

According to the invention, this object is achieved by a syringe devicesuitable for fixing on a flask that has a cylindrical body, an openingsurrounded by a flange presenting a side face, and a puncturable plugclosing said opening, the device being characterized in that itcomprises a guide part suitable for co-operating with said flask, and asyringe provided with a needle and mounted to slide in said guide part,said guide part including an open first end having at its terminalportion a first internal guide surface suitable for co-operating withthe cylindrical body of said flask, and fastening means for fasteningsaid part to said flange, which means are set back relative to saidfirst internal guide surface, said fastening means being activated whilesaid device is being put into place on said flask, said guide partincluding a second end and a common portion suitable for receiving saidsyringe provided with means for providing guidance in translation tosaid syringe in said guide part in order to bring said syringe into anengaged position in which its needle punctures the puncturable membraneof the flask, said guide part also having a central orifice for allowingthe end of said needle to pass through under the effect of said syringemoving in translation.

It will be understood that in this way, because of the presence of theguide surface at the end of the guide part co-operating with thecylindrical body of the flask over sufficient length, the guide part isaccurately centered relative to the puncturable plug of the flask.Consequently, the end of the needle of the syringe is properlypositioned facing the central portion of the puncturable plug of theflask, thereby enabling the plug to be punctured under optimumconditions when the syringe is pushed into the guide part. Also, sincethe syringe is guided in translation relative to the guide part, thisensures that the positioning of the needle relative to the plug ismaintained while the syringe is moving. In addition, the presence of thefastening elements makes it possible to secure the guide part, and thusthe syringe, to the flask, thus making it easier to maneuver the syringerelative to the flask. In particular, that makes it possible to monitorvery accurately how far the syringe has been pushed into the guide part,and thus how far the tip of the needle has penetrated into the flaskafter the plug has been punctured, in order to ensure that suchpenetration is kept down to a minimum. Naturally, after the operation ofmixing and then sucking the mixture back into the syringe, the syringecan be separated from the guide part.

Preferably, the first end of the guide part includes a second internalguide surface suitable for co-operating with the side wall of the flangeof the flask, the fastening means being disposed between the first andsecond guide surfaces. The presence of these two guide surfaces makes itpossible to reduce the length of the first guide surface while obtainingaccurate centering of the guide part relative to the flask.

Also preferably, in a first embodiment, the means for guiding thesyringe in translation in the guide part include sealing means forproviding sealing between the inside face of the guide part and the bodyof said syringe.

In a second embodiment, the means for guiding the syringe in the guidepart include at least one guide face formed in the inside face of theguide part and suitable for co-operating with a portion of the body ofsaid syringe.

According to another characteristic of the invention, the guide partincludes a plate element disposed substantially perpendicularly to thedirection of displacement of the syringe and in which the centralorifice is formed, the face of the plate directed towards the first endof the guide part being provided with a projecting annular ribsurrounding the central orifice, whereby said rib is pressed against theplug of said flask while said fixing means co-operate with said flask.

Other characteristics and advantages of the present invention appearmore clearly on reading the following description of various embodimentsof the invention given as non-limiting examples.

BRIEF DESCRIPTION OF THE DRAWINGS

The description refers to the accompanying drawings, in which:

FIG. 1 is a vertical section through a flask usable with the syringedevice of the invention;

FIG. 2 is a section through a first embodiment of the syringe device;

FIG. 2A illustrates a removable cap for use with a syringe deviceaccording to the invention

FIG. 3 is a perspective view of the syringe device fixed on a flask;

FIG. 4a is a detail view of FIG. 2 showing how the syringe device isfixed on a flask;

FIG. 4b is a horizontal section view on line B—B of FIG. 4a;

FIG. 5 is a view partially in perspective and partially in verticalsection, showing a second embodiment of the syringe device fixed on aflask;

FIGS. 6a to 6 c show how the syringe device is used; and

FIG. 7 is a fragmentary vertical section through a third embodiment ofthe syringe device.

DETAILED DESCRIPTION OF THE INVENTION

With reference initially to FIG. 1, there is described a flask 10 ofstandard type e.g. containing medication in lyophilized form. The flask10 comprises a cylindrical body 12 with a neck 14 defining an opening16. The neck 14 is surrounded by a cylindrical flange 18 which has aside face 20, a top face 22, and an inside face 24. The flask is closedby a plug made of puncturable material 26 which is engaged in theopening 16 of the flask. The periphery 28 of the plug is pressed againstthe top face 22 of the flange, and a metal clamping capsule 30 fixes theplug in sealed manner onto the opening 16 of the flask 10.

It will be understood on looking at FIG. 1 that the diameter D of thepuncturable central portion of the plug is relatively small, with itsdiameter lying in the range 5 mm to 2 mm, depending on the size of theflask.

With reference now to FIGS. 2 to 4, there is described a firstembodiment of a syringe device suitable for fixing on a flask of thekind shown in FIG. 1. The syringe device 40 is essentially constitutedby a guide part 42 and a syringe 44 of conventional type fitted with aneedle 45. The guide part 42 is preferably circularly symmetrical aboutthe axis XX′ and has a first end 46 for securing to the flask 10, asecond end 48 for receiving and guiding in translation the syringe 44,and an intermediate common part 50. The first end 46 comprises a firstguide surface 52 of inside diameter D′2 that is designed to co-operatewith the cylindrical portion 12 of the flask, which has a diameter D2that is slightly smaller than the diameter D′2. The end 46 includes asecond circularly symmetrical guide surface 54 designed to co-operatewith the side face 20 of the flange 18 of the flask, said guide surfacehaving an inside diameter D′1 that is slightly greater than the diameterD1 of the flange 18. Between the guide surfaces 52 and 54, the end 46 ofthe guide part includes resilient snap-fastening elements 58 serving tosecure the end 46 of the guide part 42 on the neck of the flask 10. Ascan be seen more clearly in FIGS. 2 and 4, the end 46 of the guide partis connected in its common portion by a portion 60 forming a plate thatis substantially orthogonal to the axis XX′ and that forms an integralportion of the guide part. This plate 60 is provided with an axialsleeve 62 which defines a central orifice 64 lying on the axis XX′ ofthe guide part. The central orifice 64 is extended by a frustoconicalportion 66 facing towards the second end of the guide part. When thesyringe 44 is mounted on the guide part, the end of the needle 45 liesinside the central orifice 64. The bottom face 60 a of the plate 60 ispreferably provided with an annular rib 70 surrounding the orifice 64and projecting from the face 60 a. This ensures that the guide part 42is secured to the flask, with the resilient tongues 58 co-operating withthe bottom face 24 of the flange when the rib 70 is pressed against theplug. Accurate fixing and good sealing is thus obtained between the plugand the guide part by the action of the rib on the resilient materialforming the plug of the flask. Also preferably, although notessentially, a puncturable membrane 72 can be fixed to the face 60 a ofthe plate 60, thereby sealing the zone 76 inside the guide part, andthus ensuring that the space 76 containing the needle is kept sterile.

It will be understood that because of the presence of the resilienttongues 58, the guide part is automatically secured to the neck of theflask merely by pushing the neck of the flask into the end of the guidepart, without there being any need for some other action beingperformed. The resilience of the tongues 58 ensures that they operateautomatically.

It would not go beyond the invention if the guide surface 54 were to beomitted. Under such circumstances, the surface 52 would need to be ofadequate length in the direction of the axis XX′, e.g. 5 mm, so that itis capable, on its own, of positioning the guide part on the flask.

FIG. 4b shows a variant embodiment of the guide surface 52 andoptionally of the guide surface 54. It makes it possible to achieve verygood centering of the guide part 42 on the flask in spite of dimensionaltolerances applicable to the flask. The inside face 52 a of the guidesurface is provided with at least one longitudinal rib 53, andpreferably with three such ribs disposed at 120° intervals, and of asection that is triangular or similar. The edges of said ribs can becrushed to some extent along a diameter of the particular cylindricalbody concerned, or of the flange, while still maintaining centering.

In dashed lines, FIG. 2 shows another variant embodiment of the guidepart. In this variant, the puncturable membrane 72 is replaced by a film73 (shown in dashed lines in the figure) whose periphery is fixed insealed manner to the guide part 54. This very thin sealed film has tearstarters in its center. When the guide part is put into place on theflask, the plug of the flask applies pressure to the film 73, therebycausing it to tear in its center. This ensures that the needle can passthrough it freely.

To maintain sterile conditions in the inside zone 76 of the guide part,it is also possible to provide the inside face of the guide zone 52 withtapping 200. A removable cap 202 having an outside thread 204 can thenbe screwed to the end of the guide part.

The syringe 44 is guided in translation inside the common portion of theguide part by means of an annular sealing ring 78 whose outside face 78a preferably has three sealing ribs 80, 82, and 84 that co-operate withthe guide part. The inside face 78 b of the sealing ring 78 has ashoulder 86 co-operating with the syringe body 44. Consequently, thesealing ring is entrained by the syringe when the syringe is pushed intothe guide part. In contrast, the sealing ring is free relative to thesyringe when the syringe is moved to be extracted from the guide part.The end 48 of the guide part preferably includes resilient blades 90projecting into the inside of the guide part. In the storage position,as shown in FIG. 2, the ends of the resilient blades 90 are interposedbetween the ribs 82 and 84 that serve to hold the sealing ring 78 tosome extent relative to the guide part. In this way, the syringe and theguide part are indeed secured mechanically to each other by means of thesealing ring 78 which also serves to provide dynamic sealing between theguide part and the syringe body. As also shown in FIG. 2, the guide part42 preferably has a flange 92 on its outside face serving to protect thefingers of people handling the equipment while the syringe is being putback into its initial place inside the guide part after it has beenused.

FIG. 5 shows a variant embodiment of the guide device. This variantconsists solely in another embodiment of the plate 60 and of the sleeve62. In this embodiment, the plate element which is now referenced 60′has a cylindrical sleeve 96 defining an axial bore 97 of largedimensions. In this axial bore, there is engaged an additional part 98.This part 98 includes a plate-forming portion 100 provided with the rib70′. The additional part 98 also includes a sleeve-forming portion 102which is engaged in the cylindrical sleeve 96. The sleeve 102 has afrustoconical end 104 and the central orifice 105, in similar manner tothe sleeve 62 including a frustoconical end 66. It will be understoodthat when the extra part 98 is put into place in the sleeve 96, astructure is reconstituted which is identical to that shown in FIG. 2.The advantage of this technique lies in the fact that during thepreliminary operations of preparing the syringe device, the syringe 44is placed initially in the guide part 42 while the guide part is not yetprovided with the part 98, after which the part 98 is installed via thefirst end of the guide part.

FIGS. 6a to 6 b show the syringe device in use. FIG. 6a shows both thesyringe device 40 and the flask 10 together with its puncturable plug26.

FIG. 6b shows the syringe device 40 being put into place on the flask10. The guide part 42 is accurately positioned relative to the flask andthus relative to the plug by means of the guide surfaces 52 and 54. Inaddition, the snap-fastening tongues 58 co-operate with the flange 18 ofthe flask, thereby holding the two parts together.

FIG. 6c shows the syringe being pushed into the guide part 42. This iscontrolled by the presence of the sealing ring 78. The needle 45punctures the center of the plug 26. It is then possible, by actuatingthe piston of the syringe, to cause the liquid contained in the syringeto penetrate into the flask 10. After the two substances have been mixedtogether, the mixture prepared in this way is sucked back into thesyringe. Thereafter it suffices to extract the syringe 44 from the guidepart 42, with the sealing ring 78 remaining captive in the guide partbecause of the presence of the resilient tongues 90.

In addition, in both of these first two embodiments, the syringe isguided in translation in the guide part by means of the sealing ring 78which also serves to provide sealing, and thus to ensure that the volume76 containing the needle is kept sterile. These two functions could beobtained by providing for the syringe body 44 itself to have several,e.g. three, annular ribs that are spaced apart axially and thatco-operate with the inside face of the common portion of the guide part.

With reference now to FIG. 7, there follows a description of a thirdembodiment of the syringe device. It differs from the first embodimentessentially by the fact that the sealing ring 78 is omitted and by thefact that the syringe 44 is guided in translation in the guide part 42by means specifically provided for that purpose. The remainder of thedevice is identical in both cases and is therefore not described again.

Guidance in translation is provided by co-operation between internalguide surfaces of the guide part and certain portions of the body 47 ofthe syringe. In the example shown in FIG. 7, the end of the body 47 onwhich the needle 45 is mounted presents an endpiece 120, a smalldiameter cylindrical portion 122, and a cylindrical portion 124 ofdiameter larger than that of the common portion of the syringe body.

The inside face 50 a of the common part 50 of the guide part has adiameter that is slightly greater than the outside diameter of theportion 124 of the syringe body, thereby forming a first guide surface.Inside the guide part there are provided four radially-extending guidefins 126 whose edges 126 a are disposed on a circularly cylindricalsurface whose diameter is slightly greater than that of the portion 122of the syringe body. This defines a second guide surface. The distancebetween these two guide surfaces is large enough to provide very goodguidance in translation of the syringe within the guide part, and thusaccurate centering of the needle 45 relative to the plug 26.

Naturally, only one surface need be provided, on condition that it is ofsufficient length.

It can also be seen that the top ends 126 b of the fins 126 constitutean abutment against further pushing in of the syringe by co-operatingwith the large-diameter portion 124 of the syringe body. This abutmentensures that after the syringe has been pushed into the guide part, thetip of the needle 45 has indeed passed through the plug 26 of the flask,but that it penetrates only very little into the flask. This figure alsoshows, at the top end of the guide part, reversible clip-forming tabs130 suitable for co-operating with the shoulder 124 a of the syringebody. The purpose of these tabs 130 is reliably to secure the syringe intranslation with the guide part when the syringe is fully engaged in theguide part. This makes handling the rod for controlling the syringepiston more comfortable when injecting the liquid contained in thesyringe and when sucking the mixture back out from the flask.

FIG. 7 shows another improvement which could be implemented equally wellin both of the above embodiments. This improvement relates to recoveringharmful gases that might possibly escape from the flask after thecomponents have been mixed together. Because of the excess pressure thatmay result from making the mixture in the flask and from temporary andlocal deformation of the plug when the tip of the needle leaves theplug, harmful gases or a residual fraction of liquid can penetrate intothe guide part and escape into the surrounding air.

To solve this problem, it is possible to place a part 140 of porousmaterial such as a porous foam at the first end of the guide part. Whenthe needle is being extracted from the flask, any gases escaping fromthe flask are absorbed, trapped, or blocked by the part 140. Naturally,the needle passes through the part 140.

For the same purpose, it is also possible to provide in the guide part40 an orifice that is obstructed by a microporous filter 142 making itpossible to compensate the excess pressure created by the escapinggases, by filtering said gases outside the guide part without theirtoxic components. This disposition is particularly advantageous if thequantity of gas created is large.

The filter also serves to compensate pressures inside and outside theguide part during movements of the syringe through the guide part.

It should be added that the syringe device of the invention serves notonly to ensure that the needle of the syringe and the flask areaccurately coaxial, but also to position the guide part accuratelyrelative to the flask along the axis XX′. To monitor the extent to whichthe needle has penetrated into the flask, it therefore suffices tomonitor the extent to which the syringe has penetrated into the guidepart. This result can be obtained automatically by providing an abutmentthat limits the extent to which the syringe can be pushed into the guidepart.

Although particular embodiments of the invention have been described indetail for purposes of illustration, various changes and modificationsmay be made without departing from the scope and spirit of theinvention. Accordingly, the invention is not to be limited except as bythe appended claims and equivalents thereof.

What is claimed is:
 1. An assembly comprising: a flask having acylindrical body, the flask including an opening surrounded by a flangeprovided with a side face and a puncturable plug closing said opening; asyringe device suitable for fixing on the flask, the syringe deviceincluding a guide part having a first open end provided with a terminalportion, a common portion and a second open end, the terminal portionbeing provided with a first cylindrical internal guide surface forcooperatively resting on the cylindrical flask body and with fasteningmeans located between the first cylindrical internal guide surface andthe common portion of the guide part, the fastening means beingactivatable to cooperate with a flange disposed on the flask when theguide part is connected to the flask to fasten the guide part to theflask; and a syringe having a body and a needle fixed to a first end ofthe syringe body, said needle being moveable together with the syringebody and being unconnected to said guide part to move independently ofsaid guide part, the common portion of the guide part provided withinternal guiding means for cooperatively guiding the body of the syringewhen the syringe is moved from a first position where the needle isdistant from the puncturable plug of the flask to a second positionwhere the needle passes through the puncturable plug of the flask. 2.The assembly according to claim 1, wherein said first end of said guidepart includes a second internal guide surface suitable for cooperatingwith the side face of the flange of the flask, said fastening meansbeing disposed between said first guide surface and said internalguiding means.
 3. The assembly according to claim 1, wherein saidinternal guiding means include sealing means for providing sealingbetween the inside face of said guide part and the body of said syringe.4. The assembly according to claim 3, wherein said sealing means includea sealing ring whose outside face co-operates with said guide part andwhose inside face co-operates with said syringe body.
 5. The assemblyaccording to claim 4, wherein said sealing ring is constrained to movein translation with said syringe while said syringe is being engagedinto said guide part.
 6. The assembly according to claim 1, wherein saidsyringe body includes annular ribs projecting from said syringe body forco-operating with the inside face of said guide part.
 7. The assemblyaccording to claim 1, wherein said guide part includes abutment formingmeans to limit the extent to which said syringe can be engaged in saidguide part.
 8. The assembly according to claim 13, wherein said guidepart further includes, facing said orifice, a part made of porousmaterial.
 9. The assembly according to claim 1, wherein the needle isspaced from the puncturable plug on the flask when the syringe is in thefirst position and when the guide part is fastened to the flask by thefastening means.
 10. A syringe device suitable for fixing on a flaskhaving a cylindrical body, the flask including an opening surrounded bya flange provided with a side face and a puncturable plug closing saidopening, the syringe device comprising: a guide part having a first openend provided with a terminal portion, a common portion and a second openend, the terminal portion provided with a first cylindrical internalguide surface for cooperatively resting on the cylindrical flask bodyand with fastening means located between the first cylindrical internalguide surface and the common portion of the guide member, the fasteningmeans being activatable to cooperate with a flange disposed on the flaskwhen the guide part is connected to the flask to fasten the guide partto the flask; and a syringe having a body and a needle fixed at a firstend of the syringe body, the common portion of the guide part providedwith internal guiding means for co-operatively guiding the body of thesyringe when the syringe is moved from a first position where the needleis distant from the puncturable plug of the flask to a second positionwhere the needle passes through the puncturable plug of the flask,wherein said internal guiding means include sealing means for providingsealing between the inside face of said guide part and the body of saidsyringe, said sealing means including a sealing ring whose outside facecooperates with said guide part and whose inside face cooperates withsaid syringe body, and said guide part including single-directionlocking means towards its second end and cooperating with said sealingring to hold said sealing ring and said guide part together and to allowsaid sealing ring only to be engaged in said guide part.
 11. A syringedevice suitable for fixing on a flask having a cylindrical body, theflask including an opening surrounded by a flange provided with a sideface and a puncturable plug closing said opening, the syringe devicecomprising: a guide part having a first open end provided with aterminal portion, a common portion and a second open end, the terminalportion provided with a first cylindrical internal guide surface forcooperatively resting on the cylindrical flask body and with fasteningmeans located between the first cylindrical internal guide surface andthe common portion of the guide member, the fastening means beingactivatable to cooperate with a flange disposed on the flask when theguide part is connected to the flask to fasten the guide part to theflask; and a syringe having a body and a needle fixed at a first end ofthe syringe body, the common portion of the guide part provided withinternal guiding means for cooperatively guiding the body of the syringewhen the syringe is moved from a first position where the needle isdistant from the puncturable plug of the flask to a second positionwhere the needle passes through the puncturable plug of the flask,wherein said guide part includes at least a first guide face formed inthe inside face of said guide part to cooperate with a portion of thebody of the syringe, and reversible snap fastening means for temporarilysecuring said syringe to said guide part while said syringe is fillyengaged in said guide part.
 12. The assembly according to claim 11,wherein said internal guiding means include a second guide face formedin the inside face of the guide part for co-operating with anotherportion of the body of said syringe.
 13. A syringe device suitable forfixing on a flask having a cylindrical body, the flask including anopening surrounded by a flange provided with a side face and apuncturable plug closing said opening, the syringe device comprising: aguide part having a first open end provided with a terminal portion, acommon portion and a second open end, the terminal portion provided witha first cylindrical internal guide surface for cooperatively resting onthe cylindrical flask body and with fastening means located between thefirst cylindrical internal guide surface and the common portion of theguide member, the fastening means being activatable to cooperate with aflange disposed on the flask when the guide part is connected to theflask to fasten the guide part to the flask; and a syringe having a bodyand a needle fixed at a first end of the syringe body, the commonportion of the guide part provided with internal guiding means forcooperatively guiding the body of the syringe when the syringe is movedfrom a first position where the needle is distant from the puncturableplug of the flask to a second position where the needle passes throughthe puncturable plug of the flask, wherein the first end of said guidepart is provided with an annular rib surrounding a central orificewhereby said rib is pressed against the plug of said flask when thefastening means co-operate with said flask.
 14. The assembly accordingto claim 13, wherein said guide part includes a plate element disposedsubstantially perpendicularly to the direction of displacement of thesyringe and in which said central orifice is formed, the face of saidplate directed towards the first end of said guide part being providedwith said projecting annular rib surrounding said central orifice. 15.The assembly according to claim 13, wherein the fastening means includesnap-fastening means suitable for co-operating with the face of theflange of the flask opposite from the face of the flange that receivessaid plug.
 16. The assembly according to claim 13, wherein said centralorifice is defined by a part that is added on and mounted in said firstend of the guide part, said add-on part including a sleeve-shapedportion with one end that is flared, and a portion defining said annularrib surrounding said orifice.
 17. The assembly according to claim 13,further including a puncturable membrane closing said central orifice.18. The assembly according to claim 13, further including a thin filmwhose periphery is fixed in sealed manner to the inside wall of thefirst end of said guide part in its portion which extends between saidfastening means and said central orifice, said film having tearstarters, whereby said film is opened under the action of the plug ofsaid flask when the syringe device is mounted on said flask.
 19. Asyringe device suitable for fixing on a flask having a cylindrical body,the flask including an opening surrounded by a flange provided with aside face and a puncturable plug closing said opening, the syringedevice comprising: a guide part having a first open end provided with aterminal portion, a common portion and a second open end, the terminalportion provided with a first cylindrical internal guide surface forcooperatively resting on the cylindrical flask body and with fasteningmeans located between the first cylindrical internal guide surface andthe common portion of the guide member, the fastening means beingactivatable to cooperate with a flange disposed on the flask when theguide part is connected to the flask to fasten the guide part to theflask; and a syringe having a body and a needle fixed at a first end ofthe syringe body, the common portion of the guide part provided withinternal guiding means for cooperatively guiding the body of the syringewhen the syringe is moved from a first position where the needle isdistant from the puncturable plug of the flask to a second positionwhere the needle passes through the puncturable plug of the flask, andfurther including a removable cap fixed in said first end of the guidepart.
 20. A syringe device suitable for fixing on a flask having acylindrical body, the flask including an opening surrounded by a flangeprovided with a side face and a puncturable plug closing said opening,the syringe device comprising: a guide part having a first open endprovided with a terminal portion, a common portion and a second openend, the terminal portion provided with a first cylindrical internalguide surface for cooperatively resting on a cylindrical flask body andwith fastening means located between the first cylindrical internalguide surface and the common portion of the guide member, the fasteningmeans being activatable to cooperate with a flange disposed on the flaskwhen the guide part is connected to the flask to fasten the guide partto the flask; and a syringe having a body and a needle fixed at a firstend of the syringe body, the common portion of the guide part providedwith internal guiding means for cooperatively guiding the body of thesyringe when the syringe is moved from a first position where the needleis distant from the puncturable plug of the flask to a second positionwhere the needle passes through the puncturable plug of the flask;wherein the guide part includes in its side wall an opening that isclosed by a microporous filter.